Thielavin A

Thielavin A

$375.00 - 0.50 mg

$1,315.00 - 2.50 mg

All prices in Australian dollars

Code
BIA-T1091
CAS #
71950-66-8
Molecular Formula
C29H30O10
Molecular Weight
538.5
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.

Download Data Sheets

Product Data Sheet

Application Notes

The fungal metabolite, thielavin A, and its relatives are glucose-6-phosphatase inhibitors. The three benzoic acid units are essential for inhibition. Thielavin A was originally isolated as a inhibitor of prostaglandin biosynthesis. The closely related thielavin B is a telomerase and cell wall transglycosylation inhibitor.

References

  • Thielavins as glucose-6-phosphatase (G6Pase) inhibitors: producing strain, fermentation, isolation, structural elucidation and biological activities. Sakemi S. et al., J. Antibiot. 2002, 55, 941.
  • Inhibition of telomerase activity by fungus metabolites, CRM646-A and thielavin B. Togashi K. et al., Biosci. Biotechnol. Biochem. 2001, 65, 651.
  • Screening systems for detecting inhibitors of cell wall transglycosylation in Enterococcus. Cell wall transglycosylation inhibitors in Enterococcus. Mani N. et al., J. Antibiot. 1998, 51, 471.

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