Tetrahydrolipstatin
Tetrahydrolipstatin
$195.00 - 25 mg
$55.00 - 5 mg
All prices in Australian dollars
- Code
- BIA-T1320
- Synonyms
- Orlipastat, Orlistat
- CAS #
- 96829-58-2
- Molecular Formula
- C29H53NO5
- Molecular Weight
- 495.7
- Purity
- >95% by HPLC
- Long Term Storage
- Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.
Download Data Sheets
Application Notes
Tetrahydrolipstatin (orlistat) is a semi-synthetic derivative of lipstatin, a metabolite isolated from Streptomyces toxytricini. Tetrahydrolipstatin acts as a potent, irreversible inhibitor of pancreatic lipase. In vivo, it blocks the absorption of triglycerides while allowing fatty acid absorption. Tetrahydrolipstatin is widely used for the treatment of obesity.
References
- Lipstatin, an inhibitor of pancreatic lipase, produced by Streptomyces toxytricini. I. Producing organism, fermentation, isolation and biological activity. Weibel E. et al., J. Antibiot. 1987, 40, 1081.
- Syntheses of tetrahydrolipstatin and absolute configuration of tetrahydrolipstatin and lipstatin. Barbier P. et al., Helv. Chim. Acta 1987, 70, 196.
- The total synthesis of (−)-tetrahydrolipstatin. Bodkin J. et al., Aust. J. Chem 2003, 56, 795.
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