Radicicol

Radicicol

$150.00 - 1 mg

$525.00 - 5 mg

All prices in Australian dollars

Code
BIA-R1148
Synonyms
Monorden
CAS #
12772-57-5
Molecular Formula
C18H17ClO6
Molecular Weight
364.8
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.

Download Data Sheets

Product Data Sheet

Application Notes

Radicicol is a resorcylic acid lactone, produced by several fungal species, that exhibits broad spectrum antifungal and antitumor activity. Radicicol has been the subject of extensive investigation and inhibits protein tyrosine kinase, induces the differentiation of HL-60 cells into macrophages, blocks cell cycle at G1 and G2, suppresses NIH 3T3 cell transformation by diverse oncogenes such as src, ras and mos, and also suppresses the expression of mitogen-inducible cyclooxygenase-2. As a cell differentiation modulator, radicicol has anti-angiogenic activity in vivo, inhibiting the proliferation of plasminogen activator production by vascular endothelial cells.

References

  • Some metabolites of Nectria radicicola Gerlach & Nilsson (syn. Cylindrocarpon radicicola Wr.): The structure of radicicol (monorden) Mirrington, R.N. et al., Aust. J. Chem., 1966, 19, 1265.
  • Induction of differentiation of HL-60 cells by the antifungal antibiotic, Radicicol. Shimada, Y., et al., J. Antibiot. 1995, 48, 824.
  • Radicicol inhibits tyrosine phosphorylation of the mitotic Src substrate Sam68 and retards subsequent exit from mitosis of Src-transformed cells. Pillay, I., et al., Cell. Growth Differ. 1996, 7, 1487.
  • Suppression of RAS and MOS transformation by radicicol. Zhao, J.F., et al., Oncogene 1995, 11, 161.
  • Chemistry and biology of resorcylic acid lactones. Winssinger N. and Barluenga S. Chem. Commun., 2007, 22.

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