Platencin
Platencin
$380.00 - 0.10 mg
$1,330.00 - 0.50 mg
All prices in Australian dollars
- Code
- BIA-P1178
- CAS #
- 869898-86-2
- Molecular Formula
- C24H27NO6
- Molecular Weight
- 425.5
- Purity
- >95% by HPLC
- Long Term Storage
- -20°C
- Solubility
- Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
Download Data Sheets
Application Notes
Platencin is a novel, broad spectrum, Gram-positive antibiotic produced by strains of Streptomyces platensis. Platencin is more potent than its analogue, platensimycin. Platencin shows potent in vivo efficacy without any observed toxicity. Platencin targets two essential proteins, b-ketoacyl-acyl carrier protein (ACP) synthase II (FabF) and III (FabH) whereas platensimycin targets only FabF.
References
- Isolation and Structure of Platencin: A FabH and FabF Dual Inhibitor with Potent Broad-Spectrum Antibiotic Activity. Jayasuriya H. et al., Angew. Chem. Int. Ed. 2007, 46, 4684.
- Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties. Wang J. et al., PNAS 2007, 104, 7612.
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