PF1163A

PF1163A

$225.00 - 0.50 mg

$790.00 - 2.50 mg

All prices in Australian dollars

Code
BIA-P1703
CAS #
258871-59-9
Molecular Formula
C27H43NO6
Molecular Weight
477.63
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO.

Download Data Sheets

Product Data Sheet

Application Notes

PF1163A is an unusual 13-membered depsipeptide isolated from an undescribed species of Pencillium by researchers at Meiji Seika Kaisha and reported in 2000 as an antifungal active. The macrocycle of PF1163A comprises a modified N-methyltyrosine conjugated with a 9-hydroxytetradecanoic acid. The total synthesis and absolute stereochemistry were reported in 2014. PF1163A is a selective antifungal agent with low mammalian toxicity. PF1163A acts on ergosterol biosynthesis, inhibiting C-4 sterol methyl oxidase, and acts synergistically with fluconazole against azole resistant Candida albicans.

References

  • PF1163A and B, new antifungal antibiotics produced by Penicillium sp. I. Taxonomy of producing strain, fermentation, isolation and biological activities. Hiroshi N. et al., J. Antibiot. 2000, 53, 33.
  • PF1163A and B, new antifungal antibiotics produced by Penicillium sp. Part II. Physico-chemical properties and structure elucidation. Sasaki T. et al., J. Antibiot. 2000, 53, 38.
  • PF1163A, a novel antifungal agent, inhibits ergosterol biosynthesis at C-4 sterol methyl oxidase. Nose H. et al., J. Antibiot. 2002, 55, 969.
  • Macrolides from a marine-derived fungus, Penicillium meleagrinum var. viridiflavum, showing synergistic effects with fluconazole against azole-resistant Candida albicans. Okabe M., J. Nat. Prod. 2016, 79, 1208.

Other Products

Related products