Penicinoline is an unusual quinolinone alkaloid isolated from a mangrove endophytic Penicillium species by researchers at the Key Laboratory of Marine Drugs in collaboration with Syngenta and first reported in 2010. Penicinoline posseses broad spectrum insecticidal activity and potent cytotoxic activity. In silico screening indicates that penicinoline inhibits EGFR 696-1022 T790M associated with non-small cell lung cancer.