Monascinol

Monascinol

$200.00 - 0.50 mg

$700.00 - 2.50 mg

All prices in Australian dollars

Code
BIA-M2539
Synonyms
Monascuspiloin
CAS #
1011244-19-1
Molecular Formula
C21H28O5
Molecular Weight
360.44
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in methanol or DMSO

Download Data Sheets

Product Data Sheet

Application Notes

Monascinol is a yellow-orange pigment isolated from the fungus Monascus purpureus used to produce red yeast ric . Monascinol increases the efficacy of irradiation in PC-3 prostate cancer cells, enhancing DNA damage and endoplasmic reticulum stress. Monascinol induces autophagy and cell death primarily via inhibition of the Akt/mTOR signaling pathways. Monascinol is a moderately potent inhibitor of HMG-CoA reductase. Monascinol has potent anti-androgen activity.

References

  • Monascuspiloin enhances the radiation sensitivity of human prostate cancer cells by stimulating endoplasmic reticulum stress and inducing autophagy. Chiu H-W. et al. PLoS One 2012, 7:e40462.
  • HMG-CoA reductase inhibitors from monascus-fermented rice. Li X et al. J Chem. 2013, 872056:1.
  • Screening of azaphilone derivatives from Monascus pilosus-fermented rice (red yeast rice) and their evaluation as nonsteroidal androgen receptor antagonists. Wu M-D. et al. Nat Prod Commun. 2019, 14, 1.

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