Milbemycin A3 oxime
Milbemycin A3 oxime
$300.00 - 1 mg
$1,050.00 - 5 mg
All prices in Australian dollars
- Code
- BIA-M1531
- Synonyms
- 5-Oxomilbemycin A3 oxime
- CAS #
- 114177-14-9
- Molecular Formula
- C31H43NO7
- Molecular Weight
- 541.7
- Purity
- >95% by HPLC
- Long Term Storage
- -20°C
- Solubility
- Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
Download Data Sheets
Application Notes
Milbemycin A3 oxime is a semi-synthetic macrocyclic lactone prepared by the oxidation and oximation of milbemycin A3. Milbemycin A3 oxime is the minor component (~30%) in the commercial product milbemycin oxime, marketed for endo- and exo-parasite infections. Like the other milbemycin/avermectins, milbemycin A3 oxime acts by opening glutamate sensitive chloride channels in neurons of invertebrates leading to paralysis by hyperpolarisation of these cells and signal transfer blocking.
References
- Synthesis of 5-keto-5-oxime derivatives of milbemycins and their activities against microfilariae. Tsukamoto Y. et al., Agric. Biol. Chem. 1991, 55, 2615.
- Effects of milbemycin on adult Toxocara canis in dogs with experimentally induced infection. Bowman D.D. et al., Am. J. Vet. Res. 1988, 49, 1986.
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