Micrococcin P1

Micrococcin P1

$315.00 - 0.50 mg

$1,105.00 - 2.50 mg

All prices in Australian dollars

Code
BIA-M1590
CAS #
67401-56-3
Molecular Formula
C48H49N13O9S6
Molecular Weight
1144.4
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO.

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Application Notes

Micrococcin P1 holds the remarkable position in antibiotic discovery as the first of the early antibiotics to be lost to science. Micrococcin P1 is a thiopeptide originally isolated from Micrococcus sp. by Su at Oxford in 1948. Later, Heatley and Doery purified micrococcin and defined its physico-chemical properties and activity. The producing strain was lost, causing a hiatus in research of this antibiotic family until the discovery of the related thiocillins in 1976.

References

  • Antibiotic-producing organisms in faeces and sewage. Su T.L. Brit. J. Exp. Path. 1948, 29, 466.
  • The preparation and some properties of purified micrococcin. Heatley N.G. and Doery H.M. Biochem. J. 1951, 50, 247.
  • Micrococcin P1: Structure, biology and synthesis. Ciufolini M.A. and Lefranc D. Nat. Prod. Reports 2010, 27, 330.

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