Lobaric acid

Lobaric acid

$150.00 - 0.50 mg

$525.00 - 2.50 mg

All prices in Australian dollars

Code
BIA-L1671
Synonyms
Usnetic acid
CAS #
522-53-2
Molecular Formula
C25H28O8
Molecular Weight
456.48
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO.

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Product Data Sheet

Application Notes

Lobaric acid is a hydrophobic orcinol depsidone found in a broad range of lichen species, notably within the genera, Stereocaulon and Parmelia, first reported by Asahina and Nonamura in 1935. Like many other lichen acids, lobaric acid displays a broad pharmacology. Most recently, lobaric acid was shown to inhibit cysteinyl-leukotriene formation leading to muscle contraction in Taenia coli and type 12(S)-lipoxygenase, and to interfere with protein-protein interactions. Lobaric acid is an important standard in the chemotaxonomy of lichens.

References

  • Untersuchungen uber flechtenstoffe, LVI. Mitteil.: Uber die konstitution der lobarsaure (I. Mitteil.). Asahina Y. and Nonomura S., Ber. Dtsch. Chem. Ges. 1935, 68, 1698.
  • Effect of lobaric acid on cysteinyl-leukotriene formation and contractile activity of guinea pig Taenia coli. Gissurarson S.R. et al., J. Pharmacol. Exp.Therap. 1997, 280, 770.
  • Sekikaic acid and lobaric acid target a dynamic interface of the coactivator CBP/p300. Majmudar C.Y. et al., Angew. Chem. Int. Ed. 2012, 51, 11258.
  • A catalogue of standardized chromatographic data and biosynthetic relationships for lichen substances. Elix J., 2014, Third Edition. Published by the author, Canberra, Australia.

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