Leupeptin

Leupeptin

$90.00 - 0.25 mg

$315.00 - 1 mg

All prices in Australian dollars

Code
BIA-L2465
Synonyms
L-leucinamide, Acetyl-L-leucyl-L-leucyl-L-argininal, N-acetyl-L-leucyl-L-leucyl-L-argininal
CAS #
55123-66-5
Molecular Formula
C20H38N6O4
Molecular Weight
426.55
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in methanol or DMSO

Download Data Sheets

Product Data Sheet

Application Notes

Leupeptin, a tripeptide isolated from Streptomyces sp. with a structure of Ac-L-Leu-L-Leu-L-Argal, was reported as a strong inhibitor of trypsin-family proteases in 1969. Leupeptin is active against various proteases, including papain, trypsin, plasmin, kallikrein (IC50 0.086, 0.22, 1.0 and 1.0 x 10-5M, respectively), as well as serine potease, calpain and cathepsin B. Leupeptin strongly inhibits the differentiation of the opportunitstic mycosis, Scedosporium apiospermum.

References

  • Leupeptins, new protease inhibitors from actinomycetes. Aoyagi T. et al. J Antibiot. 1969, 22, 283.
  • Protease inhibitory activity of leupeptin analogues. Sainoet T. al. J Antibiot. 1988, XLI, 220.
  • Metallopeptidase inhibitors arrest vital biological processes in the fungal pathogen Scedosporium apiospermum. Silva B.A. et al. Mycoses 2009, 54, 105.

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