The cytokinin, kinetin, was identified as a factor required for required for cell division present in vascular stem tissue and leaves of tobacco, other plants and yeast in the 1950s. Kinetin promotes cell division and wound healing in plants. Low doses of kinetin reduce apoptosis and protect mammalian cells such as HL60 cells, HaCaT human keratinocyte cells, and human peripheral lymphocytes cells from oxidative stress-mediated cell death.