Ilicicolin H
Ilicicolin H
$220.00 - 0.50 mg
$770.00 - 2.50 mg
All prices in Australian dollars
- Code
- BIA-I3086
- Synonyms
- Illicicolin H
- CAS #
- 12689-26-8
- Molecular Formula
- C27H31NO4
- Molecular Weight
- 433.5
- Purity
- >95% by HPLC
- Long Term Storage
- Soluble in methanol and DMSO.
Download Data Sheets
Application Notes
Ilicicolin H was first isolated by Hayakawa and co-workers, Shionogi & Co. Ltd, Japan from Cylindrocladium ilicicola in 1971. Ilicicolin H is a polyketide-nonribosomal peptide synthase (NRPS) with antitumor and antibacterial activity. Ilicicolin H is a potent, broad-spectrum antifungal agent and a potent inhibitor of mitochondrial respiration in yeast by binding to the Qn site of the cytochrome bc1 complex.
References
- Hayakawa S. et al. (1971). The ilicicolins, antibiotics from Cylindrocladium ilicicola. J. Antibiot. XXIV, 653.
- Gutierrez-Cirlos E.B. et al. (2004). Inhibition of the yeast cytochrome bc1 complex by ilicicolin H, a novel inhibitor that acts at the Qn site of the bc1 complex. JBC, 279, 8708.
- Xiaojing L. et al. (2019). Heterologous expression of ilicicolin H biosynthetic gene cluster and production of a new potent antifungal reagent, ilicicolin J. Molecules, 24, 2267.
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