Hymeglusin

Hymeglusin

$250.00 - 1 mg

$875.00 - 5 mg

All prices in Australian dollars

Code
BIA-H2845
Synonyms
(+)-F-(244), Antibiotic 1233A, Antibiotic F 244, F 244, L 659699
CAS #
29066-42-0
Molecular Formula
C18H28O5
Molecular Weight
324.4
Purity
>95% by HPLC
Long Term Storage
Soluble in methanol and DMSO.

Download Data Sheets

Product Data Sheet

Application Notes

Hymeglusin is a β-lactone first isolated from a fungus tentatively assigned as Cephalosporium sp. by Turner and co-workers at ICI, United Kingdom in 1970. Subsequently the metabolite was identified as a potent antifungal named Antibiotics L-659699 and F 244 isolated independently from strains of Fusarium and Scopulariopsis. Hymeglusin potently and specifically inhibits eukaryotic 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase. Hymeglusin blocks growth of Enterococcus faecalis and circumvents β-lactam resistance in methicillin-resistant S. aureus.

References

  • Aldridge D.C. et al. (1970). Antibiotic 1233A: a fungal β-lactone. J. Chem. Soc. Chem. Commun., 11, 639.
  • Tomoda H. et al. (2004). Binding site for fungal β-lactone hymeglusin on cytosolic 3-hydroxy-3-methylglutaryl coenzyme A synthase. Biochim. Biophys. Acta, 1636, 22.
  • Skaff D.A. et al. (2012). Biochemical and structural basis for inhibition of Enterococcus faecalis hydroxymethylglutaryl-CoA synthase, mvaS, by hymeglusin. Biochem., 51, 471.

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