The hodgkinsines are indole alkaloids from Hodgkinsonia frutescens (family Rubiaceae) containing three linked tryptamine units. Hodkinsine was first reported by Ritchie and co-workers, University of Sydney, in 1961. Hodgkinsineshows potent dose-​dependent analgesic activity against capsaicin-​induced pain, with low affinity for mu opioid receptors. Hodgkinsine has a broad bioprofile with potent antimicrobial activity, antifungal and cytotoxic activity. Hodgkinsine has substantial antiviral activity against DNA viruses and is a platelet aggregation inhibitor.