Granaticin A

Granaticin A

$255.00 - 1 mg

$895.00 - 5 mg

All prices in Australian dollars

Code
BIA-G2979
Synonyms
Granatomycin C, Litmomycin, N 9940A, WR 141, Antibiotic N 9940A, Antibiotic WR 141
CAS #
19879-06-2
Molecular Formula
C22H20O10
Molecular Weight
444.39
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO.

Download Data Sheets

Product Data Sheet

Application Notes

Granaticin A is a red benzoisochromanequinone pigment with antibiotic properties produced by Streptomyces vietnamensis. Granaticin is cytotoxic (ED50 3.2 µ/mL against human oral epidermoid carcinoma (KB) cells, inhibiting the maturation of ribosomal RNA. More recently, granaticin A’s putative mode of action was identified as the oxidation of sulfhydryl groups of bacterial cellular components leading to cell death from H2O2 generated during the oxidation reaction.

References

  • Products of metabolism of actinomycetes. IX. Granaticin. Corbaz R. et al. Helvetica Chimica Acta 1957, 40, 1262.
  • Litmomycin, a new antibiotic. II. Fermentation, isolation, and properties of litmomycin. Soong P. et al. Taiwan Tangye Shiyanso Yanjiu Huibao 1964, 34, 105.
  • Mechanism of action of granaticin: inhibition of ribosomal RNA maturation and cell cycle specificity. Heinstein P. J Pharm Sci. 1982, 71, 197.

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