Folipastatin
Application Notes
Folipastatin is a depsone metabolite first isolated from Aspergillus unguis by researchers at Sankyo, Japan in 1992 as an inhibitor of phospholipase A2. Folipastatin also possesses moderate antibiotic activity as against Gram positive bacteria. It is a component of a mixture of unguinol-related metabolites produced by A. unguis and A. nidulins patented as growth promotants in livestock. More recently, folipastatin was reported as an inhibitor of sterol O-acyltransferase (SOAT) 1 and 2 iso-enzymes in cell-based and enzyme assays.
References
- 7-Chlorofolipastatin, an inhibitor of sterol O-acyltransferase, produced by marine-derived Aspergillus unguis NKH-007. Uchida R. et al., J. Antibiot. 2016, 69, 647.
- Folipastatin, a new depsidone compound from Aspergillus unguis as an inhibitor of phospholipase A2: taxonomy, fermentation, isolation, structure determination and biological properties. Hamano K. et al., J. Antibiot. 1992, 45, 1195.
- Unguinol and analogs as animal growth promoters. Feighner S.D. et al., US Patent 5350763, 1994.