Epanorin

Epanorin

$235.00 - 1 mg

$825.00 - 5 mg

All prices in Australian dollars

Code
BIA-E2988
Synonyms
(-)-Epanorin, L-Epanorin
CAS #
18463-10-0
Molecular Formula
C25H25NO6
Molecular Weight
435.5
Purity
>95% by HPLC
Long Term Storage
Soluble in methanol and DMSO.

Download Data Sheets

Product Data Sheet

Application Notes

Epanorin is a yellow crystalline pigment first isolated by Zopf from the lichen Lecanora epanora in 1900. Epanorin is a member of the pulvinic acid family, with a tetronic acid core bound to the amino acid, L-leucine. Epanorin is synthesised by reacting L-leucine methyl ester with pulvinic acid lactone. Epanorin inhibits the proliferation of MCF-7 breast cancer cells and murine myeloma NS-1 cells in vitro, but is inactive against HEK-293 and human fibroblast normal cell lines. Epanorin is modestly active against Giardia duodenalis.

References

  • Frank R.L. et al. (1950). The structures and syntheses of rhiizocarpic acid and epanorin. J. Am. Chem. Soc., 72, 4454.
  • Palacios‑Moreno J. et al. (2019). Epanorin, a lichen secondary metabolite, inhibits proliferation of MCF‑7 breast cancer cells. Biol Res., 52, 55.
  • James P.J.C. et al. (2023). Synthesis, characterization, and bioactivity of the lichen pigments pulvinamide, rhizocarpic acid, and epanorin and congeners. J. Nat. Prod., 86, 550.

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