Emestrin

Emestrin

$255.00 - 1 mg

$895.00 - 5 mg

All prices in Australian dollars

Code
BIA-E1845
Synonyms
Emestrine, Mycotoxin EQ-1
CAS #
97816-62-1
Molecular Formula
C27H22N2O10S2
Molecular Weight
598.6
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO.

Download Data Sheets

Product Data Sheet

Application Notes

Emestrin is a macrocyclic mycotoxin first isolated from Emericella striata by researchers at Hoshi Unveristy, Japan in 1985. Emestrin posseses a unique epidithiodioxopiperazine ring as part of a larger heterologous macrocycle. Emestrin inhibits mitochondrial ATP synthesis via uncoupling of oxidative phosphorylation and depression of mitochondrial respiration. Emestrin is a potent antagonist of the chemokine CCR2 receptor, via inhibition of MCP-1 binding, specifically mediating monocyte chemotaxis.

References

  • Structure and absolute configuration of emestrin, a new macrocyclic epidithiodioxopiperazine from Emericella striata. Hideyuki S. et al., J.Chem. Soc. 1985, 10, 657.
  • Toxicity of emestrin, a new macrocyclic dithiodioxopiperazine mycotoxin, to mitochondrial function. Kawai K. et al., Mycotox. Res. 1989, 5, 2.
  • Isolation and structures of novel fungal metabolites as chemokine receptor (CCR2) antagonists. Herath K.B. et al., J. Antibiot. 2005, 58, 686.

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