Diazo-5-oxo-L-norleucine, 6-

Diazo-5-oxo-L-norleucine, 6-

$100.00 - 0.25 mg

$350.00 - 1 mg

All prices in Australian dollars

Code
BIA-D2480
Synonyms
L-6-Diazo-5-oxonorleucine, L-DON, NSC 7365
CAS #
157-03-9
Molecular Formula
C6H9N3O3
Molecular Weight
171.15
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in methanol or DMSO

Download Data Sheets

Product Data Sheet

Application Notes

6-Diazo-5-oxo-L-norleucine is a glutamine antagonist originally isolated from Streptomyces sp. 6-Diazo-5-oxo-L-norleucine has antitumor activity, disrupting the mitochondrial internal membrane structures of the neuroendocrine tumour cell line BON and causing DNA single-strand breaks. 6-Diazo-5-oxo-L-norleucine acts synergistically with L-asparaginase to inhibit U251, U87, and SF767 glioblastoma cells.

References

  • 6-Diazo-5-oxo-L-norleucine, a new tumor inhibitory substance. II: Isolation and characterization. Dion H.W. et al. 1954 Antibiot Chemother. 1954, 78, 3075.
  • A mechanism behind the antitumour effect of 6-diazo-5-oxo-L-norleucine (DON): disruption of mitochondria. Wu F. et al. Eur J Cancer 1999, 35, 1155.
  • DNA strand cleavage by tumor-inhibiting antibiotic 6-diazo-5-oxo-L-norleucine. Hiramoto K. et al. Mutat Res. 1996, 360, 95.

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