Alamethicin F50

Alamethicin F50

$180.00 - 2.50 mg

$630.00 - 10 mg

All prices in Australian dollars

Code
BIA-A1543
Synonyms
Alamethicin F, Alamethicin Rf 50, Atroviridin A, 18-L-Glutamine-alamethicin I
CAS #
56165-93-6
Molecular Formula
C92H151N23O24
Molecular Weight
1963.4
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.

Download Data Sheets

Product Data Sheet

Application Notes

Alamethicin F50 is a neutral linear peptaibol complex with potent antibiotic activity, containing 20 “amino acids” with acetyl and phenylalaninol termini, produced by Trichoderma sp. Alamethicin F50 acts an ionopohore, transporting ions through membranes and artificial lipid membranes. Alamethicin F50 forms voltage-dependent ion channels in lipid bilayer membranes. Alamethicin F50 is co-produced with an acidic linear peptaibol complex (alamethicin F30). Alamethicin itself is a variable mixture of the acidic and neutral components. In general, reports on alamethicin do not specify the ratio of F50 to F30 in the complex and comparative data between the complexes is scant.

References

  • A polypeptide antibacterial agent isolated from Trichoderma viride. Meyer C.E. & Reusser F. Experientia 1967, 23, 85.
  • Chemical nature and sequence of alamethicin. Martin D.R. & Williams R.J.P. Biochem. J. 1976, 153, 181.
  • Alamethacin adsporption to a planar lipid bilayer. Vodyanoy I. et al., Bipophys J. 1988, 53, 649.

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