4-Hydroxyscytalone
Application Notes
4-Hydroxyscytalone was first isolated from the rice blast pathogen, Pyricularia oryzae, reported by Iwasaki and coworkers, University of Tokyo, in 1973. The core of 4-hydroxyscytalone consists of a trihydroxy-dihydronaphthalenone. 4-Hydroxyscytalone is an intermediate in the melanin biosynthetic pathway and has noticeable activity against the plant nematode, Bursaphelenchus xylophilus.
References
- Iwasaki S. et al. (1973). Isolations of phytotoxic substances produced by pyricularia oryzae cavara. Tetrahedron, 14, 3537.
- Greenblatt G.A. & Wheeler M.H. (1986). HPLC analysis of fungal melanin intermediates and related metabolites. J. Liq. Chromatogr., 9, 971.
- Zhu Y. et al. (2008). Screening and isolation of antinematodal metabolites against Bursaphelenchus xylophilus produced by fungi. Ann. Microbiol., 58, 375.