Sordarin
Sordarin
$240.00 - 1 mg
$840.00 - 5 mg
All prices in Australian dollars
- Code
- BIA-S3090
- CAS #
- 11076-17-8
- Molecular Formula
- C27H40O8
- Molecular Weight
- 492.6
- Purity
- >95% by HPLC
- Long Term Storage
- Soluble in methanol, DMSO.
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Application Notes
Sordarin is a tetracyclic diterpene glycoside initially isolated from Sordaria araneosa by Hauser and Sigg in 1971. Sordarin derivatives were patented as fungicides by Merck and Co. in 1998. Sordarin selectively inhibits fungal protein synthesis by impairing the function of eukaryotic elongation factor 2 (eEF2). Mutations in ribosomal protein L10e confer resistance to sordarin.
References
- Hauser D. & Sigg H.P. (1971). Sordarin. 1. Isolation and degradation of sordarin. Helvetica Chim. Acta, 54, 1178.
- Justice M.C. et al. (1998). Elongation factor 2 as a novel target for selective inhibition of fungal protein synthesis. J. Biol. Chem., 273, 3148.
- Mutations in ribosomal protein L10e confer resistance to the fungal-specific eukaryotic elongation factor 2 inhibitor sordarin. Justice M.C. et al. J Biol Chem., 274, 4869.
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