Helvolic acid

Helvolic acid

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Code
BIA-H1930
Synonyms
Fumigacin, NSC 319943
CAS #
29400-42-8
Molecular Formula
C33H44O8
Molecular Weight
568.7
Purity
>95% by HPLC
Long Term Storage
Soluble in methanol or DMSO

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Product Data Sheet

Application Notes

Helvolic acid is a triterpenoid antibacterial mycotoxin produced by Aspergillus and other fungal species, structurally related to cephalosporin P1 and fusidic acid. Helvolic acid is active against Gram positive and Gram negative organisms, including Clostrium pseudomonas, Mycobacterium shigella, Salmonella typhimurium and Corynebacterium. Helvolic acid is a strong synergist of penicillin against multidrug resistant S. aureus. Helvolic acid has antitumor, antitrypanosomal, antimycobacterial and potent antiviral activity against H. pylori.

References

  • Cephalosporin P and helvolic acid. Oxley P. J Chem Soc Chem Commun. 1966, 729.
  • Helvolic acid, a secondary metabolite produced by Neosartorya spinosa KKU-​1NK1 and its biological activities. Wareerat S. et al. Chiang Mai J Sci. 2016, 43, 483.
  • In vitro synergistic antibacterial activities of helvolic acid on multi-​drug resistant Staphylococcus aureus. Ling Q. et al. Nat Prod Res. 2009, 23, 309.
  • In vitro antitrypanosomal activity of the secondary metabolites from the mutant strain IU-​3 of the insect pathogenic fungus Ophiocordyceps coccidiicola NBRC 100683. Momoko G. et al. Chem Pharm Bull. 2016, 64, 988.
  • Anti-​Helicobacter pylori substances from endophytic fungal cultures. Li Y. et al. World J Microbiol Biotech. 2005, 21, 553.

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