Anhydrofulvic acid

Anhydrofulvic acid

$240.00 - 0.50 mg

$840.00 - 2.50 mg

All prices in Australian dollars

Code
BIA-A2917
CAS #
95730-85-1
Molecular Formula
C14H10O7
Molecular Weight
290.23
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO.

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Product Data Sheet

Application Notes

Anydrofulvic acid is produced by several Penicillium and other fungal species. Anhydrofulvic acid has an essentially planar chromone ring system, with a coplanar carboxylic acid group. Anhydrofulvic acid possesses potent antifungal activity, inhibiting both endogenous and exogenous cellular respiration and strongly restricting biofilm production and hyphae formation in C. albicans by down-regulating several biofilm and morphogenesis-related genes. Anhydrofulvic acid is a collagenase inhibitor and has antiinflammatory and weak cytotoxic activity.

References

  • 7,8-Dihydroxy-3-methyl-10-oxo-1H,10H-pyrano-[4,3-b]-chromene-9-carboxylic acid. Wang J.F. et al. Acta Cryst. 2003, E59.
  • Mode of action of anhydrofulvic acid against Candida utilis ATCC42402 under acidic condition. Fujita K-I. et al. J Antibiot. 1999, 52, 628.
  • A secondary metabolite of Cercospora sp., associated with Rosa damascena Mill., inhibits proliferation, biofilm production, ergosterol synthesis and other virulence factors in Candida albicans. Bashir A. et al. Microb Ecol. 2023, 85, 1276.
  • PTP1B inhibitory and anti-inflammatory effects of secondary metabolites isolated from the marine-derived fungus Penicillium sp. JF-55. Lee D-S. et al. Marine Drugs 2013, 11, 1409.

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