Ethyl mycophenolate

Ethyl mycophenolate

$215.00 - 1 mg

$755.00 - 5 mg

All prices in Australian dollars

Code
BIA-E2562
CAS #
32483-51-5
Molecular Formula
C19H24O6
Molecular Weight
348.39
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in methanol or DMSO

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Product Data Sheet

Application Notes

Ethyl mycophenolate is the ethyl ester of mycophenolic acid produced by Penicillium brevicompactum but devoid of the antifungal activity of mycophenolic acid. There are few reports of the biological activity of ethyl mycophenolate, however its analogue mycophenolic acid displays antitumor and immunosuppressant effects, among others. Mycophenolic acid acts by inhibiting inosine monophosphate dehydrogenase, controlling the rate of de novo purine synthesis in proliferating B and T lymphocytes.

References

  • Some new metabolites related to mycophenolic acid. Campbell I.M. et al. Tetrahed Lett 1966, 7, 5107.
  • Mycophenolic acid: An anti-cancer compound with unusual properties. Carter S. B. et al., Nature 1969, 223, 848.
  • Conformational changes and stabilization of inosine 5'-monophosphate dehydrogenase associated with ligand binding and inhibition by mycophenolic acid. Nimmesgern E. et al., J. Biol. Chem. 1996, 271, 19421.

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