Malolactomycin C

Malolactomycin C

$195.00 - 0.10 mg

$685.00 - 0.50 mg

All prices in Australian dollars

Code
BIA-M1979
CAS #
189759-03-3
Molecular Formula
C62H109N3O20
Molecular Weight
1216.54
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in methanol or DMSO

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Product Data Sheet

Application Notes

Malolactomycin C, produced by Streptomyces sp., is the N-demethyl analogue of the malolactomycin family, a 40-membered macrolide. Malolactomycin C has moderate activity against selected fungi, specifically Cladosporium, Botrytis, and Pyricularia. Its analogue, malolactomycin D, has been identified as a selective Ras signal inhibitor, preferentially inhibiting the anchorage-​independent growth over anchorage-​dependent growth of Ras-​transformed NIH3T3 cells.

References

  • Malolactomycins C and D, new 40-​membered macrolides active against Botrytis. Tanaka Y. et al. J Antibiot. 1997, 50, 194.
  • Malolactomycin D, a potent inhibitor of transcription controlled by the Ras responsive element, inhibits Ras-​mediated transformation activity with suppression of MMP-​1 and MMP-​9 in NIH3T3 cells. Futamura M. et al. Oncogene 2001, 20, 6724.

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