Lupeol is a pentacyclic lupane triterpene produced by various fruits, vegetables and other plants, first isolated in 1898 and published in 1907. Lupeol is reported to have very diverse biological effects, including anti-inflammatory, anti-diabetic, hepatoprotective and cardiovascular activities. Lupeol exerts antitumor activity via downregulation of TNF-α and reduction of downstream effector levels of VEGFR-2 signaling. Lupeol attenuates protein expression of NFKB1, COX-2, and CASP3 in bovine embryos in vitro.