Chaetominine

Chaetominine

$200.00 - 0.50 mg

$700.00 - 2.50 mg

All prices in Australian dollars

Code
BIA-C1718
CAS #
918659-56-0
Molecular Formula
C22H18N4O4
Molecular Weight
402.4
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO.

Download Data Sheets

Product Data Sheet

Application Notes

Chaetominine is an unusual heterocyclic fungal metabolite isolated as a potent anti-tumor agent from an unspeciated endophytic strain of Chaetomium by researchers at Nanjing University, China in 2006. Interest in the structure of chaetominine has given rise to five independent total syntheses. Chaetominine’s origin as a plant endophyte has highlighted its role as an allelochemical providing direct advantage to its host by suppressing germination and growth of competing plant species. Lack of availability has hampered further research of its pharmacology.

References

  • Chaetominine, a cytotoxic alkaloid produced by endophytic Chaetomium sp. IFB-E015. Jiao R.H. et al., Org. Lett. 2006, 8, 5709.
  • Secondary metabolites from Aspergillus fumigatus, an endophytic fungus from the liverwort Heteroscyphus tener (Steph.) Schiffn. Xie F. et al., Chem. Biodivers. 2015, 12, 1313.
  • The four-step total synthesis of (-)-chaetominine. Peng Q-L. et al., Chem. Commun. 2014, 50, 1986.
  • Chaetominine, (+)-alantrypinone, questin, isorhodoptilometrin, and 4-hydroxybenzaldehyde produced by the endophytic fungus Aspergillus sp. YL-6 inhibit wheat (Triticum aestivum) andradish (Raphanus sativus) germination. Gui R-Y. et al., J. Plant Interact. 2015, 10, 87.

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