Folipastatin

Folipastatin

$190.00 - 0.50 mg

$665.00 - 2.50 mg

All prices in Australian dollars

Code
BIA-F1699
CAS #
139959-71-0
Molecular Formula
C23H24O5
Molecular Weight
380.43
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO.

Download Data Sheets

Product Data Sheet

Application Notes

Folipastatin is a depsone metabolite first isolated from Aspergillus unguis by researchers at Sankyo, Japan in 1992 as an inhibitor of phospholipase A2. Folipastatin also possesses moderate antibiotic activity as against Gram positive bacteria. It is a component of a mixture of unguinol-related metabolites produced by A. unguis and A. nidulins patented as growth promotants in livestock. More recently, folipastatin was reported as an inhibitor of sterol O-acyltransferase (SOAT) 1 and 2 iso-enzymes in cell-based and enzyme assays.

References

  • 7-Chlorofolipastatin, an inhibitor of sterol O-acyltransferase, produced by marine-derived Aspergillus unguis NKH-007. Uchida R. et al., J. Antibiot. 2016, 69, 647.
  • Folipastatin, a new depsidone compound from Aspergillus unguis as an inhibitor of phospholipase A2: taxonomy, fermentation, isolation, structure determination and biological properties. Hamano K. et al., J. Antibiot. 1992, 45, 1195.
  • Unguinol and analogs as animal growth promoters. Feighner S.D. et al., US Patent 5350763, 1994.

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