Fostriecin

Fostriecin

$325.00 - 0.10 mg

$1,140.00 - 0.50 mg

All prices in Australian dollars

Code
BIA-F1030
Synonyms
Phosphotrienin, CI 920, CL 1565A, PD 110161, NSC 339638
CAS #
87810-56-8
Molecular Formula
C19H26NaO9P
Molecular Weight
452.4
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in water, optimial stability in aqueous buffered solutions at pH 6.5. NOTE: hydrolysis of the phosphate ester will result from inappropriate storage.

Download Data Sheets

Product Data Sheet

Application Notes

Fostriecin is the most fully characterised member of a family of phosphate esters of a triene antibiotic. The antitumor potential of fostriecin has attracted considerable interest, focused on its mode of action as a topoisomerase II inhibitor. Subsequent research has focused on this metabolite's selective inhibition of protein phosphatase PP2A.

References

  • Chromosome condensation induced by fostriecin does not require p34cdc2 kinase activity and histone H1 hyperphosphorylation, but is associated with enhanced histone H2A and H3 phosphorylation. Guo X.W. et al., EMBO J. 1995, 14, 976.
  • Antitumor drug fostriecin inhibits the mitotic entry checkpoint and protein phosphatases 1 and 2A. Roberge M. et al., Cancer Res. 1994, 54, 6115.
  • Fostriecin, an antitumor antibiotic with inhibitory activity against serine/threonine protein phosphatases types 1 (PP1) and 2A (PP2A), is highly selective for PP2A. Walsh A. H. et al., FEBS Lett. 1997, 416, 230.

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