Caspofungin acetate

Caspofungin acetate

$290.00 - 1 mg

$1,015.00 - 5 mg

All prices in Australian dollars

Code
BIA-C1239
Synonyms
Cancidas, L-743,872, MK-0991
CAS #
179463-17-3
Molecular Formula
C52H88N10O15•2C2H4O2
Molecular Weight
1213.4
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in water and methanol or DMSO. Slightly soluble in ethanol.

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Product Data Sheet

Application Notes

Caspofungin is a semi-synthetic analogue of pneumocandin B0 with improved water solubility, a significant limitation in the development of the echinocandin class as pharmaceuticals. Caspofungin acts by inhibiting the synthesis of β-(1,3)-D-glucan, an essential component of the cell wall of susceptible fungi.

References

  • Synthesis and antifungal activity of novel cationic pneumocandin B0 derivatives. Bouffard F. A. et al., 1994. J. Med. Chem. 1994, 37, 222.
  • The fungal cell wall as a drug discovery target: SAR of novel echinocandin analogs. Balkovec J. M. Pharmacochemistry Library 1997, 28, 1.
  • In vitro preclinical evaluation studies with the echinocandin antifungal MK-0991 (L-743,872). Bartizal K. et al., Antimicrob. Agents Chemother. 1997, 41, 2326.
  • Preliminary animal pharmacokinetics of the parenteral antifungal agent MK-0991 (L-743872). Hajdu R. et al., Antimicrob. Agents Chemother. 1997, 41, 2339.

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